منابع مشابه
Vitamin D Binding Protein and Bone Health
Vitamin D binding protein (DBP) is the major carrier protein of 25-hydroxyvitamin D (25(OH) D) in the circulation, where it may serve roles in maintaining stable levels during times of decreased 25(OH) availability and in regulating delivery of 25(OH) D to target tissues. Several genetic polymorphisms of DBP have been described that lead to phenotypic changes in the protein that may affect affi...
متن کاملVitamin D and bone health
Throughout the life-cycle, the skeleton requires optimum development and maintenance of its integrity to prevent fracture. Bones break because the loads placed upon them exceed the ability of the bone to absorb the energy involved. It is now estimated that 1:3 women and 1:12 men over the age of 55 years will suffer from osteoporosis in their lifetime and in the UK, at a cost in excess of £1.7 b...
متن کاملVitamin D and Bone Health
The vitamin D3 molecule, or cholecalciferol, is now considered a hormone that acts on multiple homeostatic fronts, either skeletal or extra-skeletal. After 100 years since from its identification as a protective and curative factor of rickets, during the last decade the interest in vitamin D among scientists and general public increased substantially and the use of vitamin D supplements has inc...
متن کاملVitamin D and Bone Health
Winter 2006 • Vol. 1 – No. 3 ABSTRACT Despite the availability of a wide variety of foods and supplements, and a growing interest in nutrition, the incidence of Vitamin D defi ciency is on the rise in the United States. Because vitamin D enhances the availability of calcium for bone mineralization, disorders marked by a loss of bone strength are likewise becoming more common. The causes of this...
متن کاملRelationship of vitamin D status and bone mass according to vitamin D-binding protein genotypes
BACKGROUND Vitamin D-binding protein (DBP) may alter the biological activity of total 25-hydroxyvitamin D [25(OH)D]; this could influence on the effects of vitamin D in relation to bone mineral density (BMD) and fractures. Emerging data suggest that fetuin-A may be involved in bone metabolism. We aimed to investigate the influence of DBP gene polymorphism on the relationship of vitamin D status...
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ژورنال
عنوان ژورنال: International Journal of Endocrinology
سال: 2014
ISSN: 1687-8337,1687-8345
DOI: 10.1155/2014/561214